![]() ![]() In the present study, these polycarboxylic acids and other mitochondria-relevant metabolites underwent dehydration (alcohol-to-olefin and/or dehydrative cyclization) and reduction (hydrogenation and hydrogenolysis) to diols or triols upon reaction with H 2, catalyzed by sterically confined iridium–bipyridyl complexes. These metabolites are biorenewable resources that represent potential sustainable carbon feedstocks, provided that carbon-hydrogen bonds are restored to these molecules. ![]() ![]() The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH 2, as well as C 4-, C 5-, and C 6-polycarboxylic acids as energy-poor metabolites. The Krebs cycle is the fuel/energy source for cellular activity and therefore of paramount importance for oxygen-based life.
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